Do H63D homozygote patients have clinically significant iron overload?
نویسندگان
چکیده
منابع مشابه
Do children with primary nocturnal enuresis have clinically significant behavior problems?
OBJECTIVE To determine if primary nocturnal enuresis (PNE) is accompanied by significant behavioral comorbidity. DESIGN A survey design using a standardized behavioral rating scale. SETTING Behavioral pediatric clinics in the Midwest. PARTICIPANTS Subjects with PNE (n=92) were selected from 122 consecutive referrals for enuresis. Criteria included age 5 years or older, PNE status, and wet...
متن کاملAssociation of HFE mutations (C282Y and H63D) with iron overload in blood donors from Mexico City.
BACKGROUND AND OBJECTIVE Iron overload has been associated with HFE mutations (C282Y and H63D). We investigated the association between these mutations and high serum ferritin in a sample of healthy adult men. DESIGN AND METHODS We enrolled unrelated blood donors from three hospitals in Mexico City in a crosssectional study. Serum ferritin (SF) was determined to define iron overload, and HFE ...
متن کاملEffect of Hereditary Hemochromatosis Gene H63D and C282Y Mutations on Iron Overload in Sickle Cell Disease Patients
OBJECTIVE Hemochromatosis is an autosomal recessive disease that is one of the most important reasons for iron overload. Sickle cell disease is a hemoglobinopathy that occurs as a result of a homozygous mutation in the hemoglobin gene. Erythrocyte transfusion is frequently used in the treatment of this disease. Iron overload as a result of transfusion is important in the mortality and morbidity...
متن کاملEndocrine Dysfunctions in Iron Overload in Patients with Major Thalassemia
Abstract Background The aim of the present study was to determine the endocrine dysfunction in patients with major thalassemia, who receive hyper transfusion. Materials and Methods This cross sectional study was performed during one year, which included 65 major thalassemia patients (31 females and 34 males), aged between 14 month to 27 years old (median 10,3). Growth assessment was measur...
متن کاملAssessment of Pancreatic Iron Overload in Transfusion Dependent Thalassemic Patients
Advances in the management of transfusion dependent thalassemic patients have improved the survival of these patients. The most important consequence of repeated and frequent transfusions is iron accumulation in vital organs. The magnetic resonance imaging (MRI) is a non-invasive and valid technique for the estimation of iron stores. Despite multiple studies about cardiac and liver MRI T2*, the...
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ژورنال
عنوان ژورنال: Gut
سال: 2011
ISSN: 0017-5749
DOI: 10.1136/gut.2011.239301.530